Development of Animal Models Early animal models of asthma were developed in a variety of species (90) and focused on the phenomenon of airways hyperresponsiveness (AHR), defined as excessive bronchoconstriction in response to a standardized challenge. The challenging agent was usually a smooth muscle agonist such as methacholine or histamine.
Therefore, airway closure on ventilation imaging appears to be associated with asthma severity and poor control of type II inflammation and as such, there is a strong argument that ventilation imaging is a clinically relevant physiological measurement for characterising asthma.
Immediate mortality for patients who are mechanically ventilated for acute severe asthma is very low and is often associated with out-of-hospital cardiorespiratory arrest before intubation.
Pb Modelling The Human Ventilation System Asthma Image
