Nephrogenic Diabetes Insipidus Image

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Nephrogenic diabetes insipidus (NDI) is a rare condition of fluid balance in the kidneys. In NDI, kidneys dilute the urine too much because they are unable to control the concentration of urine due to the defective functioning of a hormone.

Symptoms include excessive thirst and excretion of large amounts of urine. Diagnosis of nephrogenic diabetes insipidus is based on tests of blood and urine. Drinking increased amounts of water helps prevent dehydration.

ABSTRACT Diabetes insipidus (DI) is a disorder characterized by excretion of large volumes of hypotonic urine. The underlying cause is either a deficiency of the hormone arginine vasopressin (AVP) in the pituitary gland/hypothalamus (central DI), or resistance to the actions of AVP in the kidneys (nephrogenic DI).