Epidemiological studies have demonstrated an association between type 2 diabetes and cancer. Type 2 diabetes is characterized by insulin resistance and hyperinsulinemia. Hyperinsulinemia may lead to cancer through insulin’s effect on its cognate receptor and the insulin-like growth factor system.
An inverse relationship has been observed between type 2 diabetes and prostate and this may be due to lower testosterone levels in men with type 2 diabetes. Medications used to treat type 2 diabetes may affect cancer cells directly or indirectly by affecting serum insulin levels.
Nevertheless, Gullo et al., 1994 reported that the T2DM could be consequence of pancreatic cancer and is more stronger in recently diagnosed individuals. Diabetes duration <1 year was reported to carry the highest risk for DPAC as reported by Ben et al. 2011. Gastric cancer