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The current USPSTF recommendation to begin CRC screening at age 50 years sets a minimal threshold for insurers; there is no prohibition against coverage for screening at an earlier age.

Poor utilization of and adherence to CRC screening is a major contributor to avoidable CRC mortality in the United States and has been a persistent challenge since the earliest prospective studies of CRC screening were conducted.

The ACS recommends that adults aged 45 years and older with an average risk of CRC undergo regular screening with either a high-sensitivity stool-based test or a structural (visual) examination, depending on patient preference and test availability.