Certainly, the scientific rationale for targeting tumor glycolysis is clearly sound and logical. It is based on the fact that tumor glycolysis is a true signature of cancer cells. A number of drug candidates have been tested mostly pre-clinically with mixed success.
Under hypoxic conditions where glycolysis remains the predominant energy producing pathway sensitizing cancer cells would require intracellular depletion of ATP by inhibition of glycolysis. Together, the oncogenic regulation of glycolysis and multifaceted roles of glycolytic components underscore the biological significance of tumor glycolysis.
Thus it is evident that aerobic glycolysis in conjunction with the pentose shunt pathway provide multiple benefits to cancer cells such as promoting tumor progression and providing resistance to therapy. Hence, this key signature of cancer cells, tumor metabolism, particularly the tumor glycolysis,…
Glycolysis Tumor Image
