However, people with nephrogenic diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected individuals can quickly become dehydrated if they do not drink enough water, especially in hot weather or when they are sick.

Your kidneys try to remove the extra glucose by passing it in your urine. In diabetes insipidus, your blood glucose levels are normal, but your kidneys can’t properly concentrate urine. How common is diabetes insipidus?

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Symptoms include excessive thirst and excretion of large amounts of urine. Diagnosis of nephrogenic diabetes insipidus is based on tests of blood and urine. Drinking increased amounts of water helps prevent dehydration.

ABSTRACT Diabetes insipidus (DI) is a disorder characterized by excretion of large volumes of hypotonic urine. The underlying cause is either a deficiency of the hormone arginine vasopressin (AVP) in the pituitary gland/hypothalamus (central DI), or resistance to the actions of AVP in the kidneys (nephrogenic DI).

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Nephrogenic diabetes insipidus (NDI) is a rare disorder that occurs when the kidneys are unable to concentrate urine. In most people, the body balances the fluids you drink with the amount of urine you excrete, or expel, from your body.

Women, on the other hand, can be carriers but cannot get this hereditary condition. Nephrogenic diabetes insipidus can result from inherited gene changes, or mutations, that prevent the kidneys from responding to vasopressin, but the overwhelming majority of causes are due to: 3

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